A formula for correlating pKa values determined in D2O and H2O

被引：445

作者：

Krezel, A

Bal, W

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland

[2] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2004年 / 98卷 / 01期

关键词：

acidity; deuterium isotope effect; pH;

D O I：

10.1016/j.jinorgbio.2003.10.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A linear correlation between pH-meter readings in equivalent D2O and H2O solutions, determined experimentally, leads to a novel equation, which allows for a direct recalculation of pK(a) values measured in D2O into a H2O equivalent: pK(H) = 0.929pK(H.) + 0.42. The comparison of this equation with the previously used approach is discussed. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：161 / 166

页数：6

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