Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae

被引:53
作者
Bousema, J. Teun [1 ]
Drakeley, Chris J. [2 ]
Mens, Petra F. [3 ]
Arens, Theo [1 ]
Houben, Rein [2 ]
Omar, Sabah A. [4 ]
Gouagna, Louis C. [5 ]
Schallig, Henk [3 ]
Sauerwein, Robert W. [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol 268, NL-6500 HB Nijmegen, Netherlands
[2] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[3] Royal Trop Inst, KIT Biomed Res, NL-1105 AZ Amsterdam, Netherlands
[4] Kenya Govt Med Res Ctr, Nairobi, Kenya
[5] Inst Rech Dev, Unite Rech 016, Ouagadougou, Burkina Faso
基金
英国惠康基金;
关键词
D O I
10.4269/ajtmh.2008.78.442
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Plasmodium falciparum and P. malariae occur endemically in many parts of Africa. Observations from malariotherapy patients suggest that co-infection with P. malariae may increase P. falciparum gametocyte production. We determined P. falciparum gametocyte prevalence and density by quantitative nucleic acid sequence-based amplification (QT-NASBA) after antimalarial treatment of Kenyan children with either P. falciparum mono-infection or P. falciparum and P. malariae mixed infection. In addition, we analyzed the relationship between mixed species infections and microscopic P. falciparum gametocyte prevalence in three datasets from previously published studies. In Kenyan children, QT-NASBA gametocyte density was increased in mixed species infections (P = 0.03). We also observed higher microscopic prevalences of P. falciparum gametocytes in mixed species infections in studies from Tanzania and Kenya (odds ratio = 2.15, 95% confidence interval = 0.99-4.65 and 2.39, 1.58-3.63) but not in a study from Nigeria. These data suggest that co-infection with P. malariae is correlated with increased P. falciparum gametocytemia.
引用
收藏
页码:442 / 448
页数:7
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