SUVi and BACH1: a new subfamily of mammalian helicases?

被引：9

作者：

Menichini, P

Linial, M

机构：

[1] Natl Inst Canc Res IST, Lab Mutagenesis, I-16132 Genoa, Italy

[2] Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

来源：

MUTATION RESEARCH-DNA REPAIR | 2001年 / 487卷 / 1-2期

关键词：

DNA helicases; RecQ family; genome integrity; genotoxic stress response;

D O I：

10.1016/S0921-8777(01)00104-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：67 / 71

页数：5

共 14 条

[1] BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function [J].