Oral ketamine therapy in the treatment of postamputation stump pain

被引:54
作者
Nikolajsen, L [1 ]
Hansen, PO [1 ]
Jensen, TS [1 ]
机构
[1] AARHUS UNIV HOSP, DANISH PAIN RES CTR, DK-8000 AARHUS C, DENMARK
关键词
stump pain; ketamine; NMDA receptor; mechanical stimuli; thermal stimuli;
D O I
10.1111/j.1399-6576.1997.tb04710.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Hyperactivity of N-methyl-D-aspartate (NMDA) receptors may be one of the factors in the maintenance of post-amputation stump pain. Case report: Ketamine - a clinical available NMDA receptor antagonist - was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion. Following infusion stump pain was alleviated for 31 hours. Ketamine reduced the allodynic area and wind-up-like pain and increased pressure-pain thresholds. Treatment was started with ketamine 50 mg x 4 per day dissolved in juice. No side effects or development of tolerance were observed during a 3-month treatment period. Conclusion: NMDA receptor antagonists may have a potential in the treatment of neuropathic pain, including stump pain.
引用
收藏
页码:427 / 429
页数:3
相关论文
共 16 条
[1]   THE EFFECT OF N-METHYL-D-ASPARTATE ANTAGONIST (KETAMINE) ON SINGLE AND REPEATED NOCICEPTIVE STIMULI - A PLACEBO-CONTROLLED EXPERIMENTAL HUMAN STUDY [J].
ARENDTNIELSEN, L ;
PETERSENFELIX, S ;
FISCHER, M ;
BAK, P ;
BJERRING, P ;
ZBINDEN, AM .
ANESTHESIA AND ANALGESIA, 1995, 81 (01) :63-68
[2]   RESPONSE OF CHRONIC NEUROPATHIC PAIN SYNDROMES TO KETAMINE - A PRELIMINARY-STUDY [J].
BACKONJA, M ;
ARNDT, G ;
GOMBAR, KA ;
CHECK, B ;
ZIMMERMANN, M .
PAIN, 1994, 56 (01) :51-57
[3]  
BENNETT GJ, 1994, 7TH P WORLD C PAIN, P495
[4]   CONTRIBUTION OF CENTRAL NEUROPLASTICITY TO PATHOLOGICAL PAIN - REVIEW OF CLINICAL AND EXPERIMENTAL-EVIDENCE [J].
CODERRE, TJ ;
KATZ, J ;
VACCARINO, AL ;
MELZACK, R .
PAIN, 1993, 52 (03) :259-285
[5]  
DEVOR M, 1989, TXB PAIN, P47
[6]   CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF THE N-METHYL-D-ASPARTIC ACID (NMDA) RECEPTOR ANTAGONIST KETAMINE IN THE TREATMENT OF POSTHERPETIC NEURALGIA [J].
EIDE, PK ;
STUBHAUG, A ;
OYE, I ;
BREIVIK, H .
PAIN, 1995, 61 (02) :221-228
[7]   RELIEF OF POSTHERPETIC NEURALGIA WITH THE N-METHYL-D-ASPARTIC ACID RECEPTOR ANTAGONIST KETAMINE - A DOUBLE-BLIND, CROSS-OVER COMPARISON WITH MORPHINE AND PLACEBO [J].
EIDE, PK ;
JORUM, E ;
STUBHAUG, A ;
BREMNES, J ;
BREIVIK, H .
PAIN, 1994, 58 (03) :347-354
[8]   NMDA receptor blockade in chronic neuropathic pain: A comparison of ketamine and magnesium chloride [J].
Felsby, S ;
Nielsen, J ;
ArendtNielsen, L ;
Jensen, TS .
PAIN, 1996, 64 (02) :283-291
[9]   SUCCESSFUL TREATMENT OF POSTHERPETIC NEURALGIA WITH ORAL KETAMINE [J].
HOFFMANN, V ;
COPPEJANS, H ;
VERCAUTEREN, M ;
ADRIAENSEN, H .
CLINICAL JOURNAL OF PAIN, 1994, 10 (03) :240-242
[10]  
Jensen TS, 1994, Textbook of pain, V3rd, P651