Drebrin expression is increased in spinal motoneurons of rats after axotomy

被引：11

作者：

Kobayashi, S

Shirao, T

Sasaki, T

机构：

[1] Gunma Univ, Sch Med, Dept Neurosurg, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ, Sch Med, Dept Neurobiol & Behav, Maebashi, Gumma 3718511, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 311卷 / 03期

关键词：

drebrin; motoneuron; axotomy; immunoreactivity; synapse; regeneration;

D O I：

10.1016/S0304-3940(01)02155-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Drebrin has been known to act on actin filaments at dendritic spines to cause morphological change, and might be related to the plasticity of synaptic transmission. In the present study, changes of drebrin were examined immunohistochemically in the spinal motoneurons of rats following unilateral sciatic nerve transection. Drebrin-immunoreactivity (-ir) in the motoneurons was significantly increased on the lesioned side after 3 days. Confocal laser-scanning microscopic images of the motoneurons revealed conspicuous increase in drebrin in the submembranous region of the cells. After 10 weeks, drebrin-ir on the lesioned side decreased to a level not significantly different from that on the unlesioned side. The results suggested that drebrin played important roles in synaptic restoration in axotomized motoneurons. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：165 / 168

页数：4

共 20 条

[1]

Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: Maintenance of core components independent of actin filaments and microtubules [J].