Differential effects of transdermal nicotine on microstructured analyses of tics in Tourette's syndrome: An open study

被引:28
作者
Dursun, SM [1 ]
Reveley, MA [1 ]
机构
[1] UNIV LEICESTER, FAC MED, DEPT PSYCHIAT, LEICESTER LE1 7RH, LEICS, ENGLAND
关键词
D O I
10.1017/S0033291796003984
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. The treatment of Tourette's syndrome (TS) is often unsatisfactory. However, there is some evidence that transdermal nicotine patch (TNP) application may improve ties of nonsmoking TS patients who are refractory to haloperidol treatment. Methods. In this open study we applied two 10 mg TNP for 2 consecutive days to four TS patients whose symptoms were not controlled by haloperidol and to a never-medicated TS patient, all of whom are non-smokers. The Yale Global Tic Severity Scale (YGTSS) and a quantified video-taped micro-structured analysis of ties (head-shake ties, eye-blinks, vocal ties, facial grimace and other body ties) were both carried out to assess the change after the application of TNP. Results. TNP application significantly reduced the YGTSS by an average of 50%, with no reported side-effects, for up to 4 weeks but not 16 weeks, as compared with TNP-free period. Consistent with these results, the total counts of ties also showed a significant decrease for up to 4 weeks after the TNP application. Conclusion. TNP application differentially affected individually quantified ties, which may suggest a differential role of nicotinic receptors in the generation of different ties.
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收藏
页码:483 / 487
页数:5
相关论文
共 17 条
[1]  
[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
[2]  
BALFOUR DJK, 1989, PROG BRAIN RES, V79, P165
[3]  
Dursun S. M., 1995, British Journal of Clinical Pharmacology, V39, p100P
[4]   LONG-LASTING IMPROVEMENT OF TOURETTES-SYNDROME WITH TRANSDERMAL NICOTINE [J].
DURSUN, SM ;
REVELEY, MA ;
BIRD, R ;
STIRTON, F .
LANCET, 1994, 344 (8936) :1577-1577
[5]   THE EFFECTS OF ALPHA-2-ADRENOCEPTOR ANTAGONISTS ON THE INHIBITION OF 1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE (DOI)-INDUCED HEAD SHAKES BY 5-HT1A RECEPTOR AGONISTS IN THE MOUSE [J].
DURSUN, SM ;
HANDLEY, SL .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (04) :1046-1052
[6]   BUSPIRONE TREATMENT OF TOURETTES-SYNDROME [J].
DURSUN, SM ;
BURKE, JG ;
REVELEY, MA .
LANCET, 1995, 345 (8961) :1366-1367
[7]   COMPLEX OF RAPID MOVEMENTS AND VOCALIZATION INDUCED BY RX336-M IN MICE - POSSIBLE RELEVANCE TO TOURETTES-SYNDROME [J].
DURSUN, SM ;
HANDLEY, SL .
JOURNAL OF PSYCHOPHARMACOLOGY, 1994, 8 (01) :27-31
[8]  
DURSUN SM, 1991, BRIT J PHARMACOL, V102, pP229
[9]   A RATING-SCALE FOR GILLES-DE-LA-TOURETTES SYNDROME - DESCRIPTION, RELIABILITY, AND VALIDITY DATA [J].
GOETZ, CG ;
TANNER, CM ;
WILSON, RS ;
SHANNON, KM .
NEUROLOGY, 1987, 37 (09) :1542-1544
[10]  
HANDLEY SL, 1992, ADV BIOSCI, V85, P235