Bioactive microbial metabolites -: A personal view

被引：2014

作者：

Bérdy, J ^{[1
]}

机构：

[1] IVAX Drug Res Inst Ltd, H-1325 Budapest, Hungary

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 01期

关键词：

bioactive microbial metabolites; biological origin; antibiotic and other bioactivities; chemical features; dereplication; the number of known compounds; future chances;

D O I：

10.1038/ja.2005.1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The short history, specific features and future prospects of research of microbial metabolites, including antibiotics and other bioactive metabolites, are summarized. The microbial origin, diversity of producing species, functions and various bioactivities of metabolites, unique features of their chemical structures are discussed, mainly on the basis of statistical data. The possible numbers of metabolites may be discovered in the future, the problems of dereplication of newly isolated compounds as well as the new trends and prospects of the research are also discussed.

引用

页码：1 / 26

页数：26

共 33 条

[1]

[Anonymous], 1995, BIOTECHNOLOGIA

[2] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[3]

BERDY I, 1985, DISCOVERY ISOLATION, P9

[4]

BERDY J, 1980, PROCESS BIOCHEM, V15, P28

[5] METABOLITES OF GENTAMICIN-PRODUCING MICROMONOSPORA SPECIES .1. ISOLATION AND IDENTIFICATION OF METABOLITES [J].

BERDY, J ;

PAUNCZ, JK ;

VAJNA, ZM ;

HORVATH, G ;

GYIMESI, J ;

KOCZKA, I .

JOURNAL OF ANTIBIOTICS, 1977, 30 (11) :945-954

[6]

Berdy J, 1974, Adv Appl Microbiol, V18, P309, DOI 10.1016/S0065-2164(08)70573-2

[7]

Berdy J., 1988, CHEM BIOTECHNOLOGY B, P269

[8]

BERDY J, 1968, PROCESS BIOCHEM, V3, P45

[9]

Berdy J., 1980, HDB ANTIBIOTIC COMPO

[10]

Berdy J, 1989, BIOACTIVE METABOLITE

← 1 2 3 4 →