Recent Advances in Acetyl-CoA Carboxylase Inhibitors

被引：11

作者：

Bourbeau, Matthew P. ^{[1
]}

Allen, John G. ^{[1
]}

Gu, Wei ^{[1
]}

机构：

[1] Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45 | 2010年 / 45卷

关键词：

FATTY-ACID OXIDATION; ENERGY-EXPENDITURE; MUTANT MICE; COENZYME-A; DERIVATIVES; POTENT; SORAPHEN; MUSCLE; LEAD;

D O I：

10.1016/S0065-7743(10)45006-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：95 / 108

页数：14

共 50 条

[1] Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal [J].

Abu-Elheiga, L ;

Matzuk, MM ;

Kordari, P ;

Oh, W ;

Shaikenov, T ;

Gu, ZW ;

Wakil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (34) :12011-12016

[2] Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets [J].

Abu-Elheiga, L ;

Oh, WK ;

Kordari, P ;

Wakil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10207-10212

[3] Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 [J].

Abu-Elheiga, L ;

Matzuk, MM ;

Abo-Hashema, KAH ;

Wakil, SJ .

SCIENCE, 2001, 291 (5513) :2613-2616

[4]

AbuElheiga L, 1997, J BIOL CHEM, V272, P10669

[5]

Anderson R., 2010, U.S. Patent, Patent No. [US20100009982A1, 20100009982]

[6]

[Anonymous], [No title captured], Patent No. 2008065508

[7] Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects [J].

Bandyopadhyay, Gautam K. ;

Yu, Joseph G. ;

Ofrecio, Jachelle ;

Olefsky, Jerrold M. .

DIABETES, 2006, 55 (08) :2277-2285

[8]

Bjorntorp Per, 1994, Current Opinion in Lipidology, V5, P166, DOI 10.1097/00041433-199405030-00003

[9]

CHANG E, 2009, Patent No. 20090035375

[10]

CHANG E, 2009, Patent No. 20090253725

← 1 2 3 4 5 →