IRAK signalling in cancer

被引：136

作者：

Rhyasen, G. W. ^{[1
,2
]}

Starczynowski, D. T. ^{[1
,2
]}

机构：

[1] Univ Cincinnati, Dept Canc Biol, Cincinnati, OH 45267 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

来源：

BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 02期

关键词：

IRAK; leukaemia; cancer; myelodysplasia; NF-kappa B; RECEPTOR-ASSOCIATED KINASE; MYELODYSPLASTIC SYNDROME; BACTERIAL-INFECTIONS; NEGATIVE REGULATOR; GENE-EXPRESSION; KAPPA-B; INTERLEUKIN-1; INHIBITORS; CELLS; INFLAMMATION;

D O I：

10.1038/bjc.2014.513

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Innate immune signalling has an essential role in inflammation, and the dysregulation of signalling components of this pathway is increasingly being recognised as an important mediator in cancer initiation and progression. In some malignancies, dysregulation of inflammatory toll-like receptor (TLR) and interleukin-1 receptor (IL1R) signalling is typified by increased NF-kappa B activity, and it occurs through somatic mutations, chromosomal deletions, and/or transcriptional deregulation. Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer targets. Although there have been previous efforts aimed at the development of IRAK kinase inhibitors, this is currently an area of renewed interest for cancer drug development.

引用

页码：232 / 237

页数：6

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