Chronic lymphocytic leukaemia genetics overview

被引：23

作者：

Caporaso, Neil

Goldin, Lynn

Plass, Christoph

Calin, George

Marti, Gerald

Bauer, Steven

Raveche, Elizabeth

McMaster, Mary Lou

Ng, David

Landgren, Ola

Slager, Susan

机构：

[1] Natl Canc Inst, Div Canc Epidemiol & Genet, Genet Epidemiol Branch, Bethesda, MD USA

[2] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol, Human Canc Genet Program, Columbus, OH 43210 USA

[3] Ohio State Univ, Immunol & Med Genet & Comprehens Canc Ctr, Dept Mol Virol, Columbus, OH 43210 USA

[4] US FDA, Ctr Biol Evaluat & Res, NIH, Div Cell & Gene Therapies,Cellular & Tissue T, Bethesda, MD USA

[5] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA

[6] Mayo Clin, Coll Med, Dept Hlth Sci Res, Div Biostat, Rochester, MN USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 05期

关键词：

genetic association; linkage; susceptibility; candidate genes; chronic lymphocytic leukaemia; family studies;

D O I：

10.1111/j.1365-2141.2007.06846.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world-wide collaborative networks that accelerated progress has become apparent. In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy.

引用

页码：630 / 634

页数：5

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