New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum

被引：40

作者：

Hosoya, T

Yamamoto, Y

Uehara, Y

Hayashi, M

Komiyama, K

Ishibashi, M ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba 2638522, Japan

[2] Nat Inst Infect Dis, Dept Bioact Mol, Tokyo 1080071, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 11期

关键词：

myxomycete; Lycogala epidendrum; bisindole; cytotoxicity; tyrosine kinase inhibitor;

D O I：

10.1016/j.bmcl.2005.03.103

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two new bisindole alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3-10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2776 / 2780

页数：5

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