Vibrio cholerae tolC is required for bile resistance and colonization

被引：143

作者：

Bina, JE ^{[1
]}

Mekalanos, JJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 07期

关键词：

D O I：

10.1128/IAI.69.7.4681-4685.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.

引用

页码：4681 / 4685

页数：5

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