Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma

被引:87
作者
An, Xin [1 ,2 ]
Ding, Pei-Rong [2 ,3 ]
Wang, Feng-Hua [1 ,2 ]
Jiang, Wen-Qi [1 ,2 ]
Li, Yu-Hong [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Dept Med Oncol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China
[2] State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Colorectal Surg, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China
关键词
Chemoradiotherapy; Neutrophil to lymphocyte ratio; Nasopharyngeal carcinoma; Radiotherapy; Prognosis; CONCURRENT CHEMORADIOTHERAPY; HEPATOCELLULAR-CARCINOMA; PREOPERATIVE NEUTROPHIL; SYSTEMIC INFLAMMATION; PHASE-III; CANCER; SURVIVAL; RESECTION; RADIOTHERAPY; EXPRESSION;
D O I
10.1007/s13277-010-0124-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Elevated neutrophil to lymphocyte ratio (NLR) has been reported to be associated with worse survival in many malignancies, whereas its role in nasopharyngeal carcinoma (NPC) remains unclear. We retrospectively reviewed 363 consecutively, newly diagnosed, non-disseminated, and biopsy-proven NPC patients. Disease-specific survival (DSS), distant metastasis-free survival (DMFS), and locoregional recurrence-free survival (LRFS) rates were compared according to NLR level. Multivariate analysis was performed to assess the prognostic value of NLR. The 5-year DSS, DMFS, and LRFS rates for patients with elevated or non-elevated NLR (> or <= 3.73) were 59.6% vs. 76.6% (p=0.03), 69.7% vs. 86.6% (p=0.002), and 78.5% vs. 87.3% (p=0.105), respectively. For patients with locoregionally advanced disease, NLR was not only an independent prognostic factor, but also a predictor of response to chemoradiotherapy. The 5-year DSS, DMFS, and LRFS rates for patients with elevated or non-elevated NLR were 47.2% vs. 73.7% (p<0.001), 59.2% vs. 85.1% (p<0.001), and 72.3% vs. 84.6% (p=0.041), respectively. Compared with radiation alone, chemoradiotherapy significantly improved DSS and LRFS for patients with non-elevated NLR, but not for those with elevated NLR. Pretreatment NLR is a strong prognostic factor for NPC patients. For patients with locoregionally advanced disease, NLR might also be a useful indicator for selection of treatment strategies.
引用
收藏
页码:317 / 324
页数:8
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