Semi-automated carbohydrate-deficient transferrin in primary biliary cirrhosis: A pilot study

被引:8
作者
Bean, P
Husa, A
Liegmann, K
Sundrehagen, E
机构
[1] Millennium Strategies, Madison, WI 53717 USA
[2] Axis Biochem, Grunerlokka, Oslo, Norway
[3] Specialty Labs Inc, Santa Monica, CA 90404 USA
来源
ALCOHOL AND ALCOHOLISM | 1998年 / 33卷 / 06期
关键词
D O I
10.1093/alcalc/33.6.657
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Primary biliary cirrhosis (PBC) is one of the few non-alcohol induced liver pathologies which causes false positive results in the evaluation of carbohydrate-deficient transferrin (CDT) for the diagnosis of alcohol misuse. This phenomenon has only been observed when using the CDTect assay (Pharmacia & Upjohn, Uppsala, Sweden). In this study, we evaluated CDT in female PBC patients (n = 14) by a new CDT procedure, the %CDT turbidimetric immunoassay (TIA, Axis Biochemicals, Oslo, Norway) using the isoelectric focusing/immunoblotting/laser densitometry (IEF/IB/LD, Specialty Laboratories, Santa Monica, CA, USA) procedure as the gold standard. One of the PBC patients tested CDT+ by IEF/IB/LD (cut-off >9 densitometry units, DU) and %CDT TIA (cut off >6%); one patient tested at the cut-off point of the IEF/IB/LD and another one tested at the cut-off point of the %CDT TIA. Thus, unlike CDTect, the %CDT TIA is a procedure that produces few false positives in PBC.
引用
收藏
页码:657 / 660
页数:4
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