Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System - Review and Perspective

被引：78

作者：

Ago, Tetsuro ^{[1
]}

Kuroda, Junya

Kamouchi, Masahiro

Sadoshima, Junichi ^{[2
]}

Kitazono, Takanari

机构：

[1] Kyushu Univ, Dept Med & Clin Sci, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Cell Biol & Mol Med, Newark, NJ 07103 USA

来源：

CIRCULATION JOURNAL | 2011年 / 75卷 / 08期

关键词：

NADPH oxidase/Nox; Reactive oxygen species; Vascular diseases; HYPOXIA-INDUCIBLE FACTOR-2-ALPHA; OXYGEN SPECIES PRODUCTION; II-MEDIATED HYPERTENSION; NAD(P)H OXIDASE; ANGIOTENSIN-II; SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS; UP-REGULATION; NOX-FAMILY; TRANSCRIPTIONAL REGULATION;

D O I：

10.1253/circj.CJ-11-0388

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system. (Circ J 2011; 75: 1791-1800)

引用

页码：1791 / 1800

页数：10

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