Synthesis of an iminosugar based peptidomimetic analogue

被引：22

作者：

Chery, F ^{[1
]}

Murphy, PV ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Chem, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

peptidomimetic; scaffold; deoxynojirimycin; azasugar; 1-deoxymannojirimycin; protease inhibitor;

D O I：

10.1016/j.tetlet.2004.01.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-deoxymannojirimycin based analogue of a known HIV-protease inhibitor is described. The strategies employed for introduction of the pharmocophore groups onto the azasugar scafford were based on regioselective reactions of the hydroxly groups of the natural product and of D-fructopyranoside derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2067 / 2069

页数：3

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