Partial response to anakinra in life-threatening Henoch-Schnlein purpura: case report

被引：13

作者：

Boyer, Erynn M. ^{[1
]}

Turman, Martin ^{[2
]}

O'Neil, Kathleen M. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Div Rheumatol, Oklahoma City, OK 73190 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Div Nephrol, Oklahoma City, OK 73190 USA

来源：

PEDIATRIC RHEUMATOLOGY | 2011年 / 9卷

关键词：

FAMILIAL MEDITERRANEAN-FEVER; OF-THE-LITERATURE; SCHONLEIN-PURPURA; KAWASAKI-DISEASE; WEGENERS-GRANULOMATOSIS; SYSTEMIC VASCULITIS; NEPHRITIS; CHILDREN; THERAPY; ETANERCEPT;

D O I：

10.1186/1546-0096-9-21

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Henoch-Schonlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening Henoch-Schonlein vasculitis that produced renal failure, pulmonary hemorrhage and vasculitis of the brain. Her response supports the theory that interleukin-1 may be an important mediator in this disease. Further study of interleukin-1 antagonists in severe Henoch-Schonlein purpura may be warranted.

引用

页数：5

共 43 条

[1]

Antoniu SA, 2007, CURR OPIN INVEST DR, V8, P927

[2]

Treatment of refractory Churg-Strauss-Syndrome (CSS) by TNF-α blockade [J].

Arbach, O ;

Gross, WL ;

Gause, A .

IMMUNOBIOLOGY, 2002, 206 (05) :496-501

[3]

Vasculitis in siblings with familial Mediterranean fever: a report of three cases and review of the literature [J].

Balbir-Gurman, Alexandra ;

Nahir, Abraham Menahem ;

Braun-Moscovici, Yolanda .

CLINICAL RHEUMATOLOGY, 2007, 26 (07) :1183-1185

[4]

Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schonlein purpura [J].

Besbas, N ;

Duzova, A ;

Topaloglu, R ;

Gok, F ;

Ozaltin, F ;

Ozen, S ;

Bakkaloglu, A .

CLINICAL RHEUMATOLOGY, 2001, 20 (04) :293-296

[5]

The role of cytokines in Henoch Schonlein Purpura [J].

Besbas, N ;

Saatci, U ;

Ruacan, S ;

Ozen, S ;

Sungur, A ;

Bakkaloglu, A ;

ElNahas, AM .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1997, 26 (06) :456-460

[6]

Non-complementaemic urticarial vasculitis: successful treatment with the IL-1 receptor antagonist, anakinra [J].

Botsios, C. ;

Sfriso, P. ;

Punzi, L. ;

Todesco, S. .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2007, 36 (03) :236-237

[7]

Infliximab Treatment of Intravenous Immunoglobulin-Resistant Kawasaki Disease [J].

Burns, Jane C. ;

Best, Brookie M. ;

Mejias, Asuncion ;

Mahony, Lynn ;

Fixler, David E. ;

Jafri, Hasan S. ;

Melish, Marian E. ;

Jackson, Mary Anne ;

Asmar, Basim I. ;

Lang, David J. ;

Connor, James D. ;

Capparelli, Edmund V. ;

Keen, Monica L. ;

Mamun, Khalid ;

Keenan, Gregory F. ;

Ramilo, Octavio .

JOURNAL OF PEDIATRICS, 2008, 153 (06) :833-838

[8]

Long-term outcome in children after Henoch-Schonlein purpura nephritis [J].

Butani, Lavjay ;

Morgenstern, Bruce Z. .

CLINICAL PEDIATRICS, 2007, 46 (06) :505-511

[9]

FAMILIAL MEDITERRANEAN FEVER AFTER RECOVERY FROM SCHONLEIN-HENOCH SYNDROME [J].

CAGLAR, MK .

ARTHRITIS AND RHEUMATISM, 1983, 26 (12) :1536-1536

[10]

Biologic therapy in primary systemic vasculitis of the young [J].

Eleftheriou, Despina ;

Melo, Marianna ;

Marks, Stephen D. ;

Tullus, Kjell ;

Sills, John ;

Cleary, Gavin ;

Dolezalova, Pavla ;

Ozen, Seza ;

Pilkington, Clarissa ;

Woo, Pat ;

Klein, Nigel ;

Dillon, Michael J. ;

Brogan, Paul A. .

RHEUMATOLOGY, 2009, 48 (08) :978-986

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