Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis

被引:40
作者
Karginov, VA
Robinson, TM
Riemenschneider, J
Golding, B
Kennedy, M
Shiloach, J
Alibek, K
机构
[1] Adv Biosyst Inc, Manassas, VA 20110 USA
[2] CBER, FDA, Bethesda, MD USA
[3] NIDDK, NIH, Bethesda, MD USA
[4] George Mason Univ, Ctr Biodef, Manassas, VA USA
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2004年 / 40卷 / 01期
关键词
anthrax treatment; anti-protective antigen antibody; ciprofloxacin; mouse model;
D O I
10.1016/S0928-8244(03)00302-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Currently there is no effective treatment for inhalational anthrax beyond administration of antibiotics shortly after exposure. There is need for new, safe and effective treatments to supplement traditional antibiotic therapy. Our study was based on the premise that simultaneous inhibition of lethal toxin action with antibodies and blocking of bacterial growth by antibiotics will be beneficial for the treatment of anthrax. In this study, we tested the effects of a combination treatment using purified rabbit or sheep anti-protective antigen (PA) antibodies and the antibiotic ciprofloxacin in a rodent anthrax model. In mice infected with a dose of Bacillus anthracis Sterne strain corresponding to 10 LD50, antibiotic treatment with ciprofloxacin alone only cured 50% of infected animals. Administration of anti-PA IgG in combination with ciprofloxacin produced 90-100% survival. These data indicate that a combination of antibiotic/immunoglobulin therapy is more effective than antibiotic treatment alone in a rodent anthrax model. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:71 / 74
页数:4
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