Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness
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de las Fuentes, Lisa
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
de las Fuentes, Lisa
[1
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Gu, C. Charles
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Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Gu, C. Charles
[2
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Mathews, Santhosh J.
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Mathews, Santhosh J.
[1
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Reagan, Joann L.
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Reagan, Joann L.
[1
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Ruthmann, Nicholas P.
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Ruthmann, Nicholas P.
[1
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Waggoner, Alan D.
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Waggoner, Alan D.
[1
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Lai, Chung-Fang
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Washington Univ, Sch Med, Div Bone & Mineral Dis, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Lai, Chung-Fang
[3
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Towler, Dwight A.
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Washington Univ, Sch Med, Div Bone & Mineral Dis, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Towler, Dwight A.
[3
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Davila-Roman, Victor G.
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Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USAWashington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
Davila-Roman, Victor G.
[1
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机构:
[1] Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Div Bone & Mineral Dis, St Louis, MO 63110 USA
Background: Osteopontin ( OPN)-transgenic mice exhibit increased carotid artery intima-media thickness ( CIMT), smooth muscle cell proliferation, and atheroma formation. Methods: An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present ( + MetS; n = 70) or absent ( + MetS; n = 70). Results: The G-allele frequency was 22%. For the entire cohort, the G group ( TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group ( P =.008); similar analysis by metabolic syndrome group found a significant difference only in the - MetS group ( P =.018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT ( P =.007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states. Conclusion: Humans with the OPN - 66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.