Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness

被引:23
作者
de las Fuentes, Lisa [1 ]
Gu, C. Charles [2 ]
Mathews, Santhosh J. [1 ]
Reagan, Joann L. [1 ]
Ruthmann, Nicholas P. [1 ]
Waggoner, Alan D. [1 ]
Lai, Chung-Fang [3 ]
Towler, Dwight A. [3 ]
Davila-Roman, Victor G. [1 ]
机构
[1] Washington Univ, Sch Med, Div Cardiovasc, Cardiovas Imaging & Clin Res Core Lab, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Div Bone & Mineral Dis, St Louis, MO 63110 USA
关键词
metabolic syndrome; carotid arteries; arteriosclerosis; genetics; growth substances;
D O I
10.1016/j.echo.2008.02.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Osteopontin ( OPN)-transgenic mice exhibit increased carotid artery intima-media thickness ( CIMT), smooth muscle cell proliferation, and atheroma formation. Methods: An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present ( + MetS; n = 70) or absent ( + MetS; n = 70). Results: The G-allele frequency was 22%. For the entire cohort, the G group ( TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group ( P =.008); similar analysis by metabolic syndrome group found a significant difference only in the - MetS group ( P =.018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT ( P =.007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states. Conclusion: Humans with the OPN - 66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.
引用
收藏
页码:954 / 960
页数:7
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