Inflammatory heart disease: a role for cytokines

被引：77

作者：

Fairweather, D

Rose, NR

机构：

[1] Johns Hopkins Med Inst, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

来源：

LUPUS | 2005年 / 14卷 / 09期

关键词：

autoimmunity; cytokines; inflammation; myocarditis; virus;

D O I：

10.1191/0961203305lu2192oa

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory heart disease is a rising concern worldwide. Similar mechanisms link autoimmune diseases, including the association of increased disease with proinflammatory cytokines and the importance of regulatory mechanisms in the control of chronic inflammation. Many pathogens including bacteria, protozoa and viruses have been associated with heart disease in patients, and are able to induce similar disease in animal models. Recognition of pathogens by the innate immune system leads to release of proinflammatory cytokines that both reduce infection and increase chronic inflammatory heart disease. Elevated levels of proinflammatory cytokines are able to overcome tolerance to chronic disease, indicating that environmental factors are important in determining progression to chronic heart disease. Understanding the mechanisms leading to chronic heart disease will be critical for developing effective therapies to reduce cardiac dysfunction and heart failure.

引用

收藏

页码：646 / 651

页数：6

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