Meanderings of the mRNA through the ribosome

被引：19

作者：

Culver, GM ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biochem BIophys & Mol Biol, Ames, IA 50011 USA

来源：

STRUCTURE | 2001年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0969-2126(01)00649-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A map of how mRNA travels through the ribosome is critical for any detailed understanding of the process of translation. This feat has recently been achieved using X-ray crystallography. The structure reveals, for the first time, details of the interactions between the mRNA and the 30S subunit beyond those at the tRNA binding sites. Elements of both 16S rRNA and ribosomal proteins contribute to mRNA binding. This work also identifies two tunnels that the mRNA passes through as it wraps around the 30S subunit. The mechanisms and mechanics of reading frame selection, translational fidelity, and translocation can now be informed by the structure.

引用

页码：751 / 758

页数：8

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