Introns and protein revolution - An analysis of the exon/intron organisation of actin genes

被引：17

作者：

Bagavathi, S ^{[1
]}

Malathi, R ^{[1
]}

机构：

[1] UNIV MADRAS,DR ALM POST GRAD INST BASIC MED SCI,DEPT GENET,MADRAS 600113,TAMIL NADU,INDIA

来源：

FEBS LETTERS | 1996年 / 392卷 / 01期

关键词：

actin gene; intron; molecular evolution; gene structure analysis;

D O I：

10.1016/0014-5793(96)00769-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A catalogue of intron positions obtained from a large number of actin genes has been compiled with a view to understanding the possible origin of intervening sequences. Actins are ubiquitous proteins conserved in evolution and an analysis of their gene structures from various organisms has revealed that there may be at least 25 intron positions distributed at different positions in the coding regions. A comparison of intron positions from a wide range of organisms from that of yeast to human actins shows that introns could be more ancestral in origin. The conservation in the observed intron patterns within the different tissue types hints at a possible functional significance of introns in present day actin genes.

引用

页码：63 / 65

页数：3

共 36 条

[1] A COMPLEX GENE SUPERFAMILY ENCODES ACTIN IN PETUNIA [J].

BAIRD, WV ;

MEAGHER, RB .

EMBO JOURNAL, 1987, 6 (11) :3223-3231

[2]

CARROLL SL, 1986, J BIOL CHEM, V261, P8965

[3] SELFISH DNA AND THE ORIGIN OF INTRONS [J].

CAVALIERSMITH, T .

NATURE, 1985, 315 (6017) :283-284

[4] THE COMPLETE SEQUENCE OF THE CHICKEN ALPHA-CARDIAC ACTIN GENE - A HIGHLY CONSERVED VERTEBRATE GENE [J].

CHANG, KS ;

ROTHBLUM, KN ;

SCHWARTZ, RJ .

NUCLEIC ACIDS RESEARCH, 1985, 13 (04) :1223-1237

[5] NON-MUSCLE CONTRACTILE PROTEINS - ROLE OF ACTIN AND MYOSIN IN CELL MOTILITY AND SHAPE DETERMINATION [J].

CLARKE, M ;

SPUDICH, JA .

ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :797-822

[6] COMPLETE NUCLEOTIDE-SEQUENCE OF A SEA-URCHIN ACTIN GENE [J].

COOPER, AD ;

CRAIN, WR .

NUCLEIC ACIDS RESEARCH, 1982, 10 (13) :4081-4092

[7] STRUCTURE AND EXPRESSION OF A SINGLE ACTIN GENE IN VOLVOX-CARTERI [J].

CRESNAR, B ;

MAGES, W ;

MULLER, K ;

SALBAUM, JM ;

SCHMITT, R .

CURRENT GENETICS, 1990, 18 (04) :337-346

[8] SPECULATIONS ON THE EARLY COURSE OF EVOLUTION [J].

DARNELL, JE ;

DOOLITTLE, WF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) :1271-1275

[9] INDEPENDENT GENE EVOLUTION IN THE POTATO ACTIN GENE FAMILY DEMONSTRATED BY PHYLOGENETIC PROCEDURES FOR RESOLVING GENE CONVERSIONS AND THE PHYLOGENY OF ANGIOSPERM ACTIN GENES [J].

DROUIN, G ;

DOVER, GA .

JOURNAL OF MOLECULAR EVOLUTION, 1990, 31 (02) :132-150

[10] DNA-SEQUENCE ANALYSIS AND STRUCTURAL RELATIONSHIPS AMONG THE CYTOSKELETAL ACTIN GENES OF THE SEA-URCHIN STRONGYLOCENTROTUS-PURPURATUS [J].

DURICA, DS ;

GARZA, D ;

RESTREPO, MA ;

HRYNIEWICZ, MM .

JOURNAL OF MOLECULAR EVOLUTION, 1988, 28 (1-2) :72-86

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