The potential usefulness of taurine on diabetes mellitus and its complications

被引：194

作者：

Ito, Takashi ^{[1
]}

Schaffer, Stephen W. ^{[2
]}

Azuma, Junichi ^{[1
]}

机构：

[1] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Chuo Ku, Kobe, Hyogo 6508530, Japan

[2] Univ S Alabama, Coll Med, Dept Pharmacol, Mobile, AL 36688 USA

来源：

AMINO ACIDS | 2012年 / 42卷 / 05期

关键词：

Taurine; Diabetic mellitus; Diabetic complications; Obesity; Insulin resistance; ATHEROSCLEROTIC LESION DEVELOPMENT; INDUCED HYPERTROPHIC GROWTH; CONGESTIVE HEART-FAILURE; PANCREATIC BETA-CELLS; DIETARY TAURINE; OXIDATIVE STRESS; HIGH-GLUCOSE; ENDOTHELIAL DYSFUNCTION; PLATELET-AGGREGATION; INSULIN SENSITIVITY;

D O I：

10.1007/s00726-011-0883-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness.

引用

页码：1529 / 1539

页数：11

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