Magnetic biochips: a new option for sensitive diagnostics

被引：123

作者：

Megens, M ^{[1
]}

Prins, M ^{[1
]}

机构：

[1] Philips Res Labs, NL-5656 AA Eindhoven, Netherlands

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

biosensor; medical diagnostics; giant magneto-resistance effect; magnetic actuation; integration; microdevices; assays; magnetic sensor; BARC; dynabeads; microchip;

D O I：

10.1016/j.jmmm.2005.02.046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We present an overview of miniaturized biosensor devices based on the sensitive detection of magnetic nanoparticles using the giant magneto-resistance effect. This detection principle has advantages over established methods, and the sensitivity is promising. In our opinion, the challenge is now in the integration-of sample pretreatment, in a cartridge, of nanoparticles with proper stabilization, magnetic properties, and surface functionalizations. (c) 2005 Published by Elsevier B.V.

引用

页码：702 / 708

页数：7

共 28 条

[1] Aytur T., 2002, SOL STAT SENS ACT MI, P126
[2] GIANT MAGNETORESISTANCE OF (001)FE/(001) CR MAGNETIC SUPERLATTICES
BAIBICH, MN
BROTO, JM
FERT, A
VANDAU, FN
PETROFF, F
EITENNE, P
CREUZET, G
FRIEDERICH, A
CHAZELAS, J
[J]. PHYSICAL REVIEW LETTERS, 1988, 61 (21) : 2472 - 2475
[3] A biosensor based on magnetoresistance technology
Baselt, DR
Lee, GU
Natesan, M
Metzger, SW
Sheehan, PE
Colton, RJ
[J]. BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) : 731 - 739
[4] Detection of a single magnetic microbead using a miniaturized silicon Hall sensor
Besse, PA
Boero, G
Demierre, M
Pott, V
Popovic, R
[J]. APPLIED PHYSICS LETTERS, 2002, 80 (22) : 4199 - 4201
[5] Detection of superparamagnetic markers with GMI-sensors
Bethke, C
Yakabchuk, H
Tarasenko, V
Hammer, H
Kisker, E
Koppers, E
Christoph, S
Zirwes, R
Müller, J
[J]. TECHNISCHES MESSEN, 2003, 70 (12): : 574 - 576
[6] ENHANCED MAGNETORESISTANCE IN LAYERED MAGNETIC-STRUCTURES WITH ANTIFERROMAGNETIC INTERLAYER EXCHANGE
BINASCH, G
GRUNBERG, P
SAURENBACH, F
ZINN, W
[J]. PHYSICAL REVIEW B, 1989, 39 (07): : 4828 - 4830
[7] COEHOORN R, 2003, HDB MAGNETIC MAT
[8] The BARC biosensor applied to the detection of biological warfare agents
Edelstein, RL
Tamanaha, CR
Sheehan, PE
Miller, MM
Baselt, DR
Whitman, LJ
Colton, RJ
[J]. BIOSENSORS & BIOELECTRONICS, 2000, 14 (10-11) : 805 - 813
[9] Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited)
Ferreira, HA
Graham, DL
Freitas, PP
Cabral, JMS
[J]. JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) : 7281 - 7286
[10] High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors
Graham, DL
Ferreira, HA
Freitas, PP
Cabral, JMS
[J]. BIOSENSORS & BIOELECTRONICS, 2003, 18 (04) : 483 - 488

← 1 2 3 →