The cellular immunology associated with autoimmune thrombocytopenic purpura: An update

被引：23

作者：

Semple, JW ^{[1
]}

Lazarus, AH ^{[1
]}

Freedman, J ^{[1
]}

机构：

[1] St Michaels Hosp, Div Haematol, Toronto Platelet Immunobiol Grp, Toronto, ON M5B 1W8, Canada

来源：

TRANSFUSION SCIENCE | 1998年 / 19卷 / 03期

关键词：

D O I：

10.1016/S0955-3886(98)00038-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic autoimmune thrombocytopenic purpura (AITP) is an organ specific autoimmune bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in increased pc-mediated platelet destruction by macrophages in the reticuloendothelial system. Although AITP is primarily mediated by IgG autoantibodies, their production is regulated by the influence of T lymphocytes and antigen presenting cells (APC). This review argues that enhanced T helper cell/antigen presenting cell interactions in patients with AITP may be responsible for IgG anti-platelet autoantibody production. Understanding these cellular immune responses in AITP may lead to the development of more immune specific therapies for the management of this disease. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：245 / 251

页数：7

共 44 条

[1] Serum levels of GM-CSF are elevated in patients with thrombocytopenia [J].

Abboud, MR ;

Laver, J ;

Xu, FS ;

Weksler, B ;

Bussel, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 92 (02) :486-488

[2]

Bang Annie, 1996, Blood, V88, p162A

[3]

BERCHTOLD P, 1989, BLOOD, V74, P1600

[4]

BLANCHETTE VS, 1992, SEMIN HEMATOL, V29, P72

[5]

BOUCHONNET F, 1994, J IMMUNOL, V153, P1921

[6] DIAGNOSIS, TREATMENT AND PATHOPHYSIOLOGY OF AUTOIMMUNE THROMBOCYTOPENIAS [J].

CHONG, BH .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 1995, 20 (03) :271-296

[7] HUMAN MONOCYTE INTERACTION WITH ANTIBODY-COATED PLATELETS .1. GENERAL-CHARACTERISTICS [J].

COURT, WS ;

CHRISTENSEN, AK ;

SACKS, RW ;

LOBUGLIO, AF .

AMERICAN JOURNAL OF HEMATOLOGY, 1984, 17 (03) :225-236

[8]

DAS SK, 1981, BLOOD, V58, P630

[9] IMMUNOLOGICALLY IGNORANT AUTOREACTIVE T-CELLS, EPITOPE SPREADING AND REPERTOIRE LIMITATION [J].

ELSON, CJ ;

BARKER, RN ;

THOMPSON, SJ ;

WILLIAMS, NA .

IMMUNOLOGY TODAY, 1995, 16 (02) :71-76

[10]

FIORENTINO DF, 1991, J IMMUNOL, V146, P3444

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