Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis

被引:120
作者
Milan, M
Campuzano, S
GarciaBellido, A
机构
[1] CSIC, CTR BIOL MOL SEVERO OCHOA, MADRID 28049, SPAIN
[2] UNIV AUTONOMA MADRID, MADRID 28049, SPAIN
关键词
imaginal disc; morphogenesis; evagination; vein patterning;
D O I
10.1073/pnas.93.21.11687
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In metamorphosing wing discs, progression through the cell cycle takes place, as in larval discs, in nonclonally derived clusters of cells synchronized in the same cell cycle stage. Contrary to early discs, there are temporal and spatial heterogeneities in cell proliferation associated with wing margin, vein, intervein, and middle intervein territories. Within these territories, there are no indications of a wave progression of the cell cycle. Mitotic orientations are, as in early discs, at random but there is a preferential allocation of postmitotic cells along the proximodistal axis, thus explaining the elongated shape of the resulting clones along this axis. Shapes of clones in mature discs and in evaginated wings are similar, thus excluding major morphogenetic movements during evagination. After the proliferative period, all the cells are arrested in G(1) phase. The final number of cells of the wing is fixed independently of experimental perturbations that alter the cell division schedule. These results are discussed in the context of a model of wing morphogenesis.
引用
收藏
页码:11687 / 11692
页数:6
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