Multiple positive and negative regulators of signaling by the EGF-receptor

被引：284

作者：

Moghal, N

Sternberg, PW

机构：

[1] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80025-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effecters and negative regulators, as well as regulation by heterodimerization between family members and crosstalk between heterologous signaling pathways. Besides serving as a paradigm for receptor tyrosine kinases in general, this family is crucial for development and is often mutated or amplified in human tumors.

引用

页码：190 / 196

页数：7

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