In vitro killing of Candida albicans by fatty acids and monoglycerides

被引：219

作者：

Bergsson, G

Arnfinnsson, J

Steingrímsson, O

Thormar, H

机构：

[1] Univ Iceland, Inst Biol, IS-108 Reykjavik, Iceland

[2] Univ Iceland, Sch Med, Dept Anat, Reykjavik, Iceland

[3] Natl Univ Hosp Reykjavik, Dept Microbiol, Reykjavik, Iceland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3209-3212.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

引用

页码：3209 / 3212

页数：4

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