Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats

被引：63

作者：

Korivi, Mallikarjuna ^{[3
]}

Hou, Chien-Wen ^{[3
]}

Huang, Chih-Yang ^{[4
,5
]}

Lee, Shin-Da ^{[5
]}

Hsu, Ming-Fen ^{[3
]}

Yu, Szu-Hsien ^{[3
]}

Chen, Chung-Yu ^{[3
]}

Liu, Yung-Yang ^{[1
,2
]}

Kuo, Chia-Hua ^{[3
,6
]}

机构：

[1] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Chest Dept, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Taipei Phys Educ Coll, Dept Sports Sci, Lab Exercise Biochem, Taipei 11153, Taiwan

[4] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

[5] China Med Univ, Grad Inst Chinese Med, Taichung 40402, Taiwan

[6] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung 40402, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

LIPID-PEROXIDATION; FREE-RADICALS; SWIMMING EXERCISE; PANAX-GINSENG; ANTIOXIDANT; DAMAGE; RG1; CELLS;

D O I：

10.1155/2012/932165

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study determined the hepatoprotective properties of ginsenoside-Rg1 against exhaustive exercise-induced oxidative stress in rats. Forty rats were assigned into vehicle and ginsenoside-Rg1 groups (0.1 mg/kg bodyweight). After 10-week treatment, ten rats from each group performed exhaustive swimming. Estimated oxidative damage markers, including thiobarbituric acid reactive substance (TBARS) (67%) and protein carbonyls (56%), were significantly (P < 0.01) elevated after exhaustive exercise but alleviated in ginsenoside-Rg1 pretreated rats. Furthermore, exhaustive exercise drastically decreased glutathione (GSH) content (similar to 79%) with concurrent decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. However, these changes were attenuated in Rg1 group. Additionally, increased xanthine oxidase (XO) activity and nitric oxide (NO) levels after exercise were also inhibited by Rg1 pretreatment. For the first time, our findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.

引用

页数：8

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