Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families

被引：16

作者：

Xiao, W-J. ^{[1
]}

Ke, Y-H. ^{[1
]}

He, J-W. ^{[1
]}

Zhang, H. ^{[1
]}

Yu, J-B. ^{[1
]}

Hu, W-W. ^{[1
]}

Gu, J-M. ^{[1
]}

Gao, G. ^{[1
]}

Yue, H. ^{[1
]}

Wang, C. ^{[1
]}

Hu, Y-Q. ^{[1
]}

Li, M. ^{[1
]}

Liu, Y-J. ^{[1
]}

Fu, W-Z. ^{[1
]}

Zhang, Z-L. ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Osteoporosis & Bone Dis, Metab Bone Dis & Genet Res Unit, Shanghai 200233, Peoples R China

来源：

OSTEOPOROSIS INTERNATIONAL | 2012年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ALOX12; ALOX15; Peak bone mineral density; Quantitative transmission disequilibrium test; SINGLE-NUCLEOTIDE POLYMORPHISM; PPAR-GAMMA INSUFFICIENCY; MASS; BMD; PREMENOPAUSAL; RECEPTOR; CLONING; SCREEN; CDNA;

D O I：

10.1007/s00198-011-1835-3

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Association between ten single-nucleotide polymorphisms (SNPs) in the human ALOX12 and ALOX15 genes and variations in peak bone mineral density (BMD) in a large sample of Chinese nuclear families with female offspring using the quantitative transmission disequilibrium test (QTDT). Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women. The aim of this study was to investigate whether polymorphisms in the human ALOX12 and ALOX15 genes are associated with variations in peak BMD in Chinese nuclear families with female offspring. Each five SNPs in the ALOX12 and ALOX15 genes were genotyped in a total of 1,260 individuals from 401 Chinese nuclear families. The BMD of the lumbar spine, femoral neck and total hip was measured by dual-energy X-ray absorptiometry. We tested whether a single SNP or a haplotype was associated with peak BMD variations using the QTDT. Using QTDT to measure within-family associations in ALOX15, we observed a significant association between rs916055 and BMD in the lumbar spine (p = 0.027 in the permutation 1,000 test). However, in ALOX12, rs312470 was significantly associated with BMD in the femoral neck (p = 0.029 and p = 0.036 in the permutation 1,000 test). The results of a haplotype analysis supported the findings of the single locus test for ALOX15. Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.

引用

页码：1889 / 1897

页数：9

共 40 条

[1]

Pedigree tests of transmission disequilibrium (Reprinted from European Journal of Human Genetics, Vol 8, pg 545-551,2000) [J].