Recent advances in monoclonal antibody therapy in IBD: practical issues

被引：34

作者：

Tamilarasan, Aravind Gokul ^{[1
]}

Cunningham, Georgina ^{[1
]}

Irving, Peter M. ^{[1
]}

Samaan, Mark A. ^{[1
]}

机构：

[1] Guys & St Thomas NHS Trust, IBD Ctr, London SE1 7EH, England

来源：

FRONTLINE GASTROENTEROLOGY | 2019年 / 10卷 / 04期

关键词：

INFLAMMATORY-BOWEL-DISEASE; VEDOLIZUMAB INDUCTION THERAPY; REAL-WORLD EXPERIENCE; CROHNS-DISEASE; MAINTENANCE THERAPY; ANTAGONIST THERAPY; ULCERATIVE-COLITIS; USTEKINUMAB; EFFICACY; OUTCOMES;

D O I：

10.1136/flgastro-2018-101054

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The advent of monoclonal antibody therapies has revolutionised inflammatory bowel disease (IBD) treatment and delivered great benefits to patients. The optimal use of this class of drugs requires careful management and a clear understanding of their properties. In this review article, we consider how to maximise the benefit of our most novel biological agents, vedolizumab and ustekinumab. For each agent, we consider practical aspects including dose flexibility, evidence for use in combination with a conventional immunomodulator and the potential role of therapeutic drug monitoring. We also address positioning of the various mechanisms and agents in treatment algorithms as well as important aspects of managing patients receiving monoclonal antibodies, such as disease reassessment. Finally, we look ahead to the future of monoclonal antibodies, where not only have biosimilars increased the number of agents available but there are also a range of novel mechanisms currently in late phase clinical trials.

引用

页码：409 / 416

页数：8

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