Screening of N-acylneuraminic acids in serum and tissue specimens of mouse C57BI with Lewis' lung cancer by high-performance liquid chromatography

被引：21

作者：

Makatsori, E ^{[1
]}

Fermani, K ^{[1
]}

Aletras, A ^{[1
]}

Karamanos, NK ^{[1
]}

Tsegenidis, T ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Sect Organ Chem Biochem & Nat Prod, GR-26110 Patras, Greece

来源：

JOURNAL OF CHROMATOGRAPHY B | 1998年 / 712卷 / 1-2期

关键词：

N-acetylneuraminic acid; N-glycolylneuraminic acid; sialic acids;

D O I：

10.1016/S0378-4347(98)00150-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum and tissue specimens from healthy C57BI mice and from mice with Lewis' lung cancer after metastasis were analyzed for N-acetyl- and N-glycolylneuraminic acid by high-performance liquid chromatography. Both neuraminic acids were present, while N-glycolylneuraminic acid was the predominant sialic acid in all tissues. Samples from mice with metastatic cancer showed a significant increase (67-200%) of total sialic acids mainly as a result of increased N-glycolylneuraminic acid synthesis. These results suggest that cancer metastasis in various tissues is closely associated with increased synthesis of the predominant neuraminic acid and may help to understand the underlying mechanisms of tumor development. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：23 / 29

页数：7

共 38 条

[1] A STUDY OF N-ACETYLNEURAMINIC ACID IN RELATION TO ITS POTENTIAL AS A MARKER OF TUMOR-DEVELOPMENT [J].

BERNS, G ;

OKENNEDY, R .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (02) :333-334

[2] BIOSYNTHESIS OF N-GLYCOLYNEURAMINIC ACID IN PORCINE SUBMANDIBULAR GLANDS - SUBCELLULAR SITE OF HYDROXYLATION OF N-ACETYLNEURAMINIC ACID IN COURSE OF GLYCOPROTEIN-BIOSYNTHESIS [J].

BUSCHER, HP ;

CASALSTENZEL, J ;

SCHAUER, R ;

MESTRESVENTURA, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 77 (02) :297-310

[3]

COLLI A, 1989, CANCER, V63, P912, DOI 10.1002/1097-0142(19890301)63:5<912::AID-CNCR2820630521>3.0.CO

[4]

2-W

[5] THE DETERMINATION OF PLASMA OR SERUM SIALIC-ACID [J].

CROOK, M .

CLINICAL BIOCHEMISTRY, 1993, 26 (01) :31-38

[6] EXPRESSION OF LEWIS(X), SIALYLATED LEWIS(X), LEWIS(A), AND SIALYLATED LEWIS(A) ANTIGENS IN HUMAN LUNG-CARCINOMA [J].

FUKUSHIMA, K .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 163 (01) :17-30

[7] DETERMINATION OF MONO-O-ACETYLATED N-ACETYLNEURAMINIC ACIDS IN HUMAN AND RAT SERA BY FLUOROMETRIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HARA, S ;

YAMAGUCHI, M ;

TAKEMORI, Y ;

FURUHATA, K ;

OGURA, H ;

NAKAMURA, M .

ANALYTICAL BIOCHEMISTRY, 1989, 179 (01) :162-166

[8] FLUOROMETRIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF N-ACETYLNEURAMINIC AND N-GLYCOLYLNEURAMINIC ACIDS AND ITS APPLICATION TO THEIR MICRODETERMINATION IN HUMAN AND ANIMAL SERA, GLYCOPROTEINS, AND GLYCOLIPIDS [J].

HARA, S ;

TAKEMORI, Y ;

YAMAGUCHI, M ;

NAKAMURA, M ;

OHKURA, Y .

ANALYTICAL BIOCHEMISTRY, 1987, 164 (01) :138-145

[9]

HARVEY HA, 1981, CANCER, V47, P324, DOI 10.1002/1097-0142(19810115)47:2<324::AID-CNCR2820470219>3.0.CO

[10]

2-L

← 1 2 3 4 →