Fatty liver -: A novel component of the metabolic syndrome

被引:638
作者
Kotronen, Anna [1 ,2 ]
Yki-Jarvinen, Hannele [1 ]
机构
[1] Univ Helsinki, Div Diabet, Dept Med, FIN-00029 Helsinki, Finland
[2] Minerva Med Res Inst, Helsinki, Finland
关键词
liver fat; metabolic syndrome; nonalcoholic liver disease;
D O I
10.1161/ATVBAHA.107.147538
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although the epidemic of obesity has been accompanied by an increase in the prevalence of the metabolic syndrome, not all obese develop the syndrome and even lean individuals can be insulin resistant. Both lean and obese insulin resistant individuals have an excess of fat in the liver which is not attributable to alcohol or other known causes of liver disease, a condition defined as nonalcoholic fatty liver disease (NAFLD) by gastroenterologists. The fatty liver is insulin resistant. Liver fat is highly significantly and linearly correlated with all components of the metabolic syndrome independent of obesity. Overproduction of glucose, VLDL, CRP, and coagulation factors by the fatty liver could contribute to the excess risk of cardiovascular disease associated with the metabolic syndrome and NAFLD. Both of the latter conditions also increase the risk of type 2 diabetes and advanced liver disease. The reason why some deposit fat in the liver whereas others do not is poorly understood. Individuals with a fatty liver are more likely to have excess intraabdominal fat and inflammatory changes in adipose tissue. Intervention studies have shown that liver fat can be decreased by weight loss, PPAR gamma agonists, and insulin therapy.
引用
收藏
页码:27 / 38
页数:12
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