Bone Marrow Stem Cells for the Treatment of Ischemic Heart Disease: A Clinical Trial Review

被引：19

作者：

Fuh, Eric ^{[1
]}

Brinton, Todd J. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, James Clark Ctr E 120, Stanford, CA 94305 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2009年 / 2卷 / 02期

关键词：

Cell Therapy; Bone Marrow Stem Cell; Chronic Myocardial Infarction; Ischemic Heart Disease; Refractory Angina; ENDOTHELIAL GROWTH-FACTOR; MYOCARDIAL GENE-TRANSFER; CORONARY-ARTERY-DISEASE; MONONUCLEAR-CELLS; INTRAMYOCARDIAL INJECTION; THERAPEUTIC ANGIOGENESIS; GUIDELINE UPDATE; ANGINA-PECTORIS; STABLE ANGINA; FOLLOW-UP;

D O I：

10.1007/s12265-009-9095-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Cardiovascular disease continues to represent a significant and growing source of morbidity and mortality despite advances in traditional treatments. As a result, increasing interest and research in regenerative therapies has emerged in recent years. Among them, cell therapy represents an area of significant potential. An expanding clinical literature now exists involving the use of bone marrow-derived stem cells in the treatment of ischemic heart disease. These early studies appear to provide promising results in patient populations that include those with refractory angina, ischemic cardiomyopathy with left ventricular dysfunction, and end-stage heart failure. This review serves to provide a comprehensive examination of these clinical trials focused on several components including cell preparation, cell delivery, safety, and efficacy of these trials.

引用

页码：202 / 218

页数：17

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