Intravenous self-administration of heroin/cocaine combinations (speedball) using nose-poke or lever-press operant responding in mice

被引:21
作者
David, V [1 ]
Polis, I [1 ]
McDonald, J [1 ]
Gold, LH [1 ]
机构
[1] Scripps Res Inst, Dept Neuropharmacol CVN7, La Jolla, CA USA
来源
BEHAVIOURAL PHARMACOLOGY | 2001年 / 12卷 / 01期
关键词
speedball; cocaine; heroin; intravenous self-administration; reward; locomotor activity; mice;
D O I
10.1097/00008877-200102000-00003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Acquisition and dose-related self-administration of heroin (H) / cocaine (C) combinations in C57BL / 6 X SJL mice were studied in nose-poke or lever-press operant responding procedures. C57BL/6 X SJL mice readily acquired self-administration in both operant procedures with a combination of doses known to be ineffective when each drug was used alone (H: 15 mug/kg and C: 150 mug/kg per injection). Similar numbers of infusions were obtained under conditions of fixed-ratio (FR) 3 versus 1 for the nose-poke and lever-press responses, respectively, Dose-effect curves for heroin:cocaine combinations revealed a pattern corresponding to a leftward shift of the dose-response for intravenous cocaine self-administration, Curves were similar whether generated with 1 or 3 days of availability per dose, or including subjects that did not respond preferentially (> 70% responses) to the hole or lever associated with drug delivery, along with those that did. Motor activity induced by a combination of low doses for each drug was examined (H: 0.375 mg/kg and C: 3.75 mg/kg, i.p.). Under these conditions, the combination of both drugs induced an initial cocaine-like stimulation of horizontal activity, in contrast to the tendency of heroin to decrease activity, It is concluded that heroin:cocaine combinations used in the present study had reinforcing effects in C57BL/6 x SJL mice, and produced a cocaine-like effect in the early part of drug-induced activity sessions, followed by a locomotor profile corresponding to the average of both drugs. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:25 / 34
页数:10
相关论文
共 32 条
[1]   REINFORCEMENT, EXPECTANCY, AND LEARNING [J].
BOLLES, RC .
PSYCHOLOGICAL REVIEW, 1972, 79 (05) :394-&
[2]   Method for training operant responding and evaluating cocaine self-administration behavior in mutant mice [J].
Caine, SB ;
Negus, SS ;
Mello, NK .
PSYCHOPHARMACOLOGY, 1999, 147 (01) :22-24
[3]   ESTABLISHMENT OF CHRONIC INTRAVENOUS DRUG SELF-ADMINISTRATION IN C57BL/6J MOUSE [J].
CARNEY, JM ;
LANDRUM, RW ;
CHENG, MS ;
SEALE, TW .
NEUROREPORT, 1991, 2 (08) :477-480
[4]  
Chang JY, 1998, J NEUROSCI, V18, P3098
[5]   Differences in the liability to self-administer intravenous cocaine between C57BL/6xSJL and BALB/cByJ mice [J].
Deroche, V ;
Caine, SB ;
Heyser, CJ ;
Polis, I ;
Koob, GF ;
Gold, LH .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 57 (03) :429-440
[6]  
DICHIARA G, 1988, J PHARMACOL EXP THER, V244, P1067
[7]   Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency [J].
Donny, EC ;
Caggiula, AR ;
Mielke, MM ;
Jacobs, KS ;
Rose, C ;
Sved, AF .
PSYCHOPHARMACOLOGY, 1998, 136 (01) :83-90
[8]   The synergistic effects of combining cocaine and heroin ("speedball") using a progressive-ratio schedule of drug reinforcement [J].
Duvauchelle, CL ;
Sapoznik, T ;
Kornetsky, C .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1998, 61 (03) :297-302
[9]   STIMULANTS - INTERACTION WITH CLINICALLY RELEVANT DRUGS [J].
ELLINWOOD, EH ;
EIBERGEN, RD ;
KILBEY, MM .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1976, 281 (DEC10) :393-408
[10]  
FOLTIN RW, 1992, J PHARMACOL EXP THER, V261, P623