Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker

被引：27

作者：

Breitenbucher, JG ^{[1
]}

Hui, HC ^{[1
]}

机构：

[1] Axys Pharmaceut Inc, So San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(98)01876-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid supported synthesis of a library of 8,448 benzopyrans was accomplished using the 4-hydroxythiophenol react and release linker. Reductive aminations were performed in parallel using a Ti(OiPr)(4)/Na(OAc)(3)BH reducing system. This reduction was performed without cleavage of resin bound substrates from the nucleophile sensitive linker. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8207 / 8210

页数：4

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