Repopulation of liver endothelium by bone-marrow-derived cells

被引:130
作者
Gao, ZH [1 ]
McAlister, VC
Williams, GM
机构
[1] Dalhousie Univ, Dept Pathol, Halifax, NS B3H 2Y9, Canada
[2] Dalhousie Univ, Dept Surg, Halifax, NS B3H 2Y9, Canada
[3] Johns Hopkins Hosp, Dept Surg, Baltimore, MD 21287 USA
关键词
D O I
10.1016/S0140-6736(00)04217-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
the mechanism underlying the immunological advantage of hepatic allografts relative to other organs is incompletely understood. We used molecular probes for the repetitive units on the Y chromosome, to identify an increasing number of male liver venous endothelial cells In needle biopsy samples of men who received female donor liver grafts, We have also shown repopulation of liver endothelium by bone marrow derived cells in a male to female mouse bone marrow transplant model. We conclude that the liver has unique venous endothelium characterised by turnover and replacement by bone marrow derived cells.
引用
收藏
页码:932 / 933
页数:2
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