Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus

被引：26

作者：

Bezard, E

Baufreton, J

Owens, G

Crossman, AR

Dudek, H

Taupignon, A

Brotchie, JM

机构：

[1] Univ Victor Segalen, Basal Gang, F-33076 Bordeaux, France

[2] Univ Victor Segalen, CNRS, UMR 5543, F-33076 Bordeaux, France

[3] Univ Manchester, Sch Biol Sci, Div Neurosci, Manchester Movement Disorder Lab, Manchester M13 9PT, Lancs, England

[4] Motac Neurosci Ltd, Manchester M15 6SE, Lancs, England

[5] Curis Inc, Cambridge, MA USA

[6] Toronto Western Hosp, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada

来源：

FASEB JOURNAL | 2003年 / 17卷 / 13期

关键词：

patched; Parkinson's disease; basal ganglia; rat; macaque;

D O I：

10.1096/fj.03-0291fje

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well established that members of the hedgehog family are involved in tissue patterning during development. We herein show that sonic hedgehog signaling molecules are differentially regulated by dopamine depletion in the basal ganglia of adult animals and specifically that sonic hedgehog levels are reduced in an animal model of Parkinson's disease. In addition, we show that sonic hedgehog protein inhibits electrical activity in the subthalamic nucleus, a key element of basal ganglia, within minutes of application. As the subthalamic nucleus is overactive in parkinsonism, we suggest that enhancement of sonic hedgehog signaling in the subthalamic nucleus may be of therapeutic value in Parkinson's disease.

引用

页码：2337 / +

页数：12

共 42 条

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