Hot off the breath: 'I've a cost for'-the 64 million dollar question

被引:21
作者
Bush, Andrew [1 ,2 ]
Simmonds, Nicholas J. [2 ,3 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Paediat Resp Med, Sydney St, London SW3 6NP, England
[2] Royal Brompton Harefield NHS Fdn Trust, London SW3 6NP, England
[3] Univ London Imperial Coll Sci Technol & Med, Dept Cyst Fibrosis, London SW3 6NP, England
关键词
RANDOMIZED CONTROLLED-TRIAL; CYSTIC-FIBROSIS; PULMONARY-FUNCTION; AZITHROMYCIN; MANAGEMENT; MUTATION; CHILDREN; ASTHMA;
D O I
10.1136/thoraxjnl-2012-201798
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
引用
收藏
页码:382 / +
页数:5
相关论文
共 14 条
[1]   Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation [J].
Accurso, Frank J. ;
Rowe, Steven M. ;
Clancy, J. P. ;
Boyle, Michael P. ;
Dunitz, Jordan M. ;
Durie, Peter R. ;
Sagel, Scott D. ;
Hornick, Douglas B. ;
Konstan, Michael W. ;
Donaldson, Scott H. ;
Moss, Richard B. ;
Pilewski, Joseph M. ;
Rubenstein, Ronald C. ;
Uluer, Ahmet Z. ;
Aitken, Moira L. ;
Freedman, Steven D. ;
Rose, Lynn M. ;
Mayer-Hamblett, Nicole ;
Dong, Qunming ;
Zha, Jiuhong ;
Stone, Anne J. ;
Olson, Eric R. ;
Ordonez, Claudia L. ;
Campbell, Preston W. ;
Ashlock, Melissa A. ;
Ramsey, Bonnie W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (21) :1991-2003
[2]  
Bush A, 2011, PEDIATR PULM, P118
[3]   Not NICE: a better way forward? [J].
Bush, Andrew ;
Lenney, Warren ;
Spencer, David ;
Warner, John O. .
ARCHIVES OF DISEASE IN CHILDHOOD, 2011, 96 (10) :907-908
[4]   Management of severe asthma in children [J].
Bush, Andrew ;
Saglani, Sejal .
LANCET, 2010, 376 (9743) :814-825
[5]   Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers [J].
Cantin, Andre M. ;
Hanrahan, John W. ;
Bilodeau, Ginette ;
Ellis, Lynda ;
Dupuis, Annie ;
Liao, Jie ;
Zielenski, Julian ;
Durie, Peter .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (10) :1139-1144
[6]   Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation [J].
Clancy, J. P. ;
Rowe, Steven M. ;
Accurso, Frank J. ;
Aitken, Moira L. ;
Amin, Raouf S. ;
Ashlock, Melissa A. ;
Ballmann, Manfred ;
Boyle, Michael P. ;
Bronsveld, Inez ;
Campbell, Preston W. ;
De Boeck, Kris ;
Donaldson, Scott H. ;
Dorkin, Henry L. ;
Dunitz, Jordan M. ;
Durie, Peter R. ;
Jain, Manu ;
Leonard, Anissa ;
Mccoy, Karen S. ;
Moss, Richard B. ;
Pilewski, Joseph M. ;
Rosenbluth, Daniel B. ;
Rubenstein, Ronald C. ;
Schechter, Michael S. ;
Botfield, Martyn ;
Ordonez, Claudia L. ;
Spencer-Green, George T. ;
Vernillet, Laurent ;
Wisseh, Steve ;
Yen, Karl ;
Konstan, Michael W. .
THORAX, 2012, 67 (01) :12-18
[7]   Cystic fibrosis mortality and survival in the UK: 1947-2003 [J].
Dodge, J. A. ;
Lewis, P. A. ;
Stanton, M. ;
Wilsher, J. .
EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (03) :522-526
[8]   A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis [J].
Elkins, MR ;
Robinson, M ;
Rose, BR ;
Harbour, C ;
Moriarty, CP ;
Marks, GB ;
Belousova, EG ;
Xuan, W ;
Bye, PTP .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (03) :229-240
[9]   Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial [J].
Equi, A ;
Balfour-Lynn, IM ;
Bush, A ;
Rosenthal, M .
LANCET, 2002, 360 (9338) :978-984
[10]   EFFECT OF AEROSOLIZED RECOMBINANT HUMAN DNASE ON EXACERBATIONS OF RESPIRATORY SYMPTOMS AND ON PULMONARY-FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS [J].
FUCHS, HJ ;
BOROWITZ, DS ;
CHRISTIANSEN, DH ;
MORRIS, EM ;
NASH, ML ;
RAMSEY, BW ;
ROSENSTEIN, BJ ;
SMITH, AL ;
WOHL, ME .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (10) :637-642