Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

被引：333

作者：

Hanover, John A. ^{[1
]}

Krause, Michael W. ^{[2
]}

Love, Dona C. ^{[1
]}

机构：

[1] NIDDK, Lab Cell & Mol Biol, NIH, Bethesda, MD 20892 USA

[2] NIDDK, Mol Biol Lab, NIH, Bethesda, MD USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 05期

关键词：

EMBRYONIC STEM-CELLS; LINKED GLCNAC TRANSFERASE; BETA-N-ACETYLGLUCOSAMINIDASE; THRIFTY PHENOTYPE HYPOTHESIS; POLYCOMB GROUP GENES; INSULIN-RESISTANCE; CAENORHABDITIS-ELEGANS; TETRATRICOPEPTIDE REPEATS; DROSOPHILA-MELANOGASTER; PROTEIN GLYCOSYLATION;

D O I：

10.1038/nrm3334

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the epigenetic regulation of gene expression. The enzymes involved in O-linked beta-D-N-acetylglucosamine (O-GlcNAc) cycling - O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) - target key transcriptional and epigenetic regulators including RNA polymerase II, histones, histone deacetylase complexes and members of the Polycomb and Trithorax groups. Thus, O-GlcNAc cycling may serve as a homeostatic mechanism linking nutrient availability to higher-order chromatin organization. In response to nutrient availability, O-GlcNAcylation is poised to influence X chromosome inactivation and genetic imprinting, as well as embryonic development. The wide range of physiological functions regulated by O-GlcNAc cycling suggests an unexplored nexus between epigenetic regulation in disease and nutrient availability.

引用

页码：312 / 321

页数：10

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