Airway remodeling and serum total immunoglobulin E (IgE) levels in a murine model of asthma

被引：6

作者：

Akkoç, T ^{[1
]}

Tolunay, S ^{[1
]}

Barlau, I ^{[1
]}

Basaran, M ^{[1
]}

机构：

[1] Marmara Univ Hosp, Pediat Allergy & Immunol Dept, Istanbul, Turkey

来源：

JOURNAL OF ASTHMA | 2001年 / 38卷 / 07期

关键词：

airway remodeling; BALB/c mice; OVA;

D O I：

10.1081/JAS-100107123

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A murine model of allergen-induced airway inflammation, epithelial phenotypic changes, and total immunoglobulin E (IgE) levels is described. Mice were sensitized to ovalbumin without adjuvant and challenged by multiple intratracheal instillations of ovalbumin by a nonsurgical technique. After repeated challenges, the basement membrane of the airway epithelium showed fibrosis, inflammatory cell infiltration at peribronchial and perivascular sites, and goblet cell hyperplasia. In addition, total IgE levels were found to be increased significantly. Further studies which will evaluate the contribution of each feature of remodeled airway to the natural history of asthma are definitely needed.

引用

页码：585 / 591

页数：7

共 20 条

[1] MARKED GOBLET CELL HYPERPLASIA WITH MUCUS ACCUMULATION IN THE AIRWAYS OF PATIENTS WHO DIED OF SEVERE ACUTE ASTHMA ATTACK [J].

AIKAWA, T ;

SHIMURA, S ;

SASAKI, H ;

EBINA, M ;

TAKISHIMA, T .

CHEST, 1992, 101 (04) :916-921

[2] Heat-killed Mycobacterium bovis-bacillus Calmette Guerin-suppressed total serum IgE response in ovalbumin-sensitized newborn mice [J].

Bakir, M ;

Tükenmez, F ;

Bahçeciler, NN ;

Barlan, IB ;

Basaran, MM .

JOURNAL OF ASTHMA, 2000, 37 (04) :329-334

[3] Lung inflammation and epithelial changes in a murine model of atopic asthma [J].

Blyth, DI ;

Pedrick, MS ;

Savage, TJ ;

Hessel, EM ;

Fattah, D .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1996, 14 (05) :425-438

[4] AIRWAY RESPONSIVENESS AND BRONCHIAL-WALL THICKNESS IN ASTHMA WITH OR WITHOUT FIXED AIR-FLOW OBSTRUCTION [J].

BOULET, LP ;

BELANGER, M ;

CARRIER, G .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (03) :865-871

[5] Airway remodeling and repair [J].

Busse, W ;

Elias, J ;

Sheppard, D ;

Banks-Schlegel, S .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (03) :1035-1042

[6] Airways remodeling is a distinctive feature of asthma and is related to severity of disease [J].

Chetta, A ;

Foresi, A ;

DelDonno, M ;

Bertorelli, G ;

Pesci, A ;

Olivieri, D .

CHEST, 1997, 111 (04) :852-857

[7] Bronchial hyperresponsiveness and airway wall remodelling induced by exposure to allergen for 9 weeks [J].

Cui, ZH ;

Skoogh, BE ;

Pullerits, T ;

Lötvall, J .

ALLERGY, 1999, 54 (10) :1074-1082

[8] Airway remodeling in asthma [J].

Elias, JA ;

Zhu, Z ;

Chupp, G ;

Homer, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (08) :1001-1006

[9] Airway remodeling and persistent airway obstruction in asthma [J].

Fish, JE ;

Peters, SP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (03) :509-516

[10] Airway smooth muscle in asthma: flirting with disaster [J].

Fredberg, JJ .

EUROPEAN RESPIRATORY JOURNAL, 1998, 12 (06) :1252-1256

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