The structural and mechanochemical cycle of kinesin

被引：57

作者：

Mandelkow, E

Johnson, KA

机构：

[1] Max Planck Unit Struct Mol Biol, D-22603 Hamburg, Germany

[2] Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(98)01278-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinesin is a microtubule-based motor protein that pulls vesicles or organelles towards the plus end of microtubules. Structural changes in the protein that drive motility are coupled to ATP binding and hydrolysis. Here, we attempt to integrate recent structural and kinetic results into a picture of the mechanochemical cycle of kinesin.

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页码：429 / 433

页数：5

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