Deciphering the role of Th17 cells in human disease

被引：249

作者：

Wilke, Cailin Moira ^{[1
,2
]}

Bishop, Keith ^{[1
,2
]}

Fox, David ^{[2
,3
]}

Zou, Weiping ^{[1
,2
,4
,5
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Grad Program Immunol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Grad Program Canc Biol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 12期

关键词：

INFLAMMATORY-BOWEL-DISEASE; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GLUCOCORTICOID RECEPTOR-BETA; EARLY RHEUMATOID-ARTHRITIS; HUMAN OVARIAN-CARCINOMA; NECROSIS-FACTOR-ALPHA; MULTIPLE-SCLEROSIS; DENDRITIC CELLS;

D O I：

10.1016/j.it.2011.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Since their identification in 2005, T helper (Th)17 cells have been proposed to play important roles in several human diseases, including various autoimmune conditions, allergy, the development and progression of tumors, and the acceptance or rejection of transplanted organs and bone marrow. Focusing on human studies, here we review recent developments regarding Th17 biology and function in each of these fields. Th17 cells actively participate in the pathogenesis of autoimmune disease, allergy and transplantation rejection. Th17 cells contribute to protective antitumor immunity in human epithelial malignancy, whereas Th17-associated cytokines may also be associated with tumor initiation and growth in the context of chronic inflammation and infection. Also discussed is how the in vivo plasticity of Th17 cells may be an important feature of Th17 cell biology in human disease.

引用

收藏

页码：603 / 611

页数：9

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