Level of functioning in autism spectrum disorders: Phenotypic congruence among affected siblings

被引：18

作者：

Goin-Kochel, Robin P. ^{[1
]}

Mazefsky, Carla A. ^{[2
,3
]}

Riley, Brien P. ^{[4
]}

机构：

[1] Baylor Univ, Texas Childrens Hosp, Houston, TX 77030 USA

[2] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[4] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2008年 / 38卷 / 06期

关键词：

AGRE; broad spectrum; twins; IQ; adaptive behavior;

D O I：

10.1007/s10803-007-0476-z

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test-Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others.

引用

页码：1019 / 1027

页数：9

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