Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis

被引：45

作者：

Boccaccio, GL

Mor, F

Steinman, L

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

INTERNATIONAL IMMUNOLOGY | 1999年 / 11卷 / 02期

关键词：

autoimmunity; cytokines; experimental autoimmune encephalomyelitis; gene therapy; multiple sclerosis; vaccination;

D O I：

10.1093/intimm/11.2.289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma.

引用

收藏

页码：289 / 296

页数：8

相关论文

共 34 条

[1] REMOVAL OF ENDOTOXIN FROM PROTEIN SOLUTIONS BY PHASE-SEPARATION USING TRITON X-114 [J].

AIDA, Y ;

PABST, MJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 1990, 132 (02) :191-195

[2] Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein [J].

Brocke, S ;

Gijbels, K ;

Allegretta, M ;

Ferber, I ;

Piercy, C ;

Blankenstein, T ;

Martin, R ;

Utz, U ;

Karin, N ;

Mitchell, D ;

Veromaa, T ;

Waisman, A ;

Gaur, A ;

Conlon, P ;

Ling, N ;

Fairchild, PJ ;

Wraith, DC ;

OGarra, A ;

Fathman, CG ;

Steinman, L .

NATURE, 1996, 379 (6563) :343-346

[3] CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity [J].

Chu, RS ;

Targoni, OS ;

Krieg, AM ;

Lehmann, PV ;

Harding, CV .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) :1623-1631

[4] Exploring the potential of DNA vaccination [J].

Cohen, IR ;

Steinman, L .

HOSPITAL PRACTICE, 1997, 32 (05) :169-&

[5] DNA vaccines [J].

Donnelly, JJ ;

Ulmer, JB ;

Shiver, JW ;

Liu, MA .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :617-648

[6] EFFECT OF ANTI-INTERFERON-GAMMA MONOCLONAL-ANTIBODY TREATMENT ON THE DEVELOPMENT OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RESISTANT MOUSE STRAINS [J].

DUONG, TT ;

FINKELMAN, FD ;

SINGH, B ;

STREJAN, GH .

JOURNAL OF NEUROIMMUNOLOGY, 1994, 53 (01) :101-107

[7] REPLACEMENT OF INSULIN-RECEPTOR TYROSINE RESIDUES 1162 AND 1163 COMPROMISES INSULIN-STIMULATED KINASE-ACTIVITY AND UPTAKE OF 2-DEOXYGLUCOSE [J].

ELLIS, L ;

CLAUSER, E ;

MORGAN, DO ;

EDERY, M ;

ROTH, RA ;

RUTTER, WJ .

CELL, 1986, 45 (05) :721-732

[8]

Ferber IA, 1996, J IMMUNOL, V156, P5

[9]

FIERZ W, 1985, J IMMUNOL, V134, P3785

[10] ADMINISTRATION OF NEUTRALIZING ANTIBODIES TO INTERLEUKIN-6 (IL-6) REDUCES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND IS ASSOCIATED WITH ELEVATED LEVELS OF IL-6 BIOACTIVITY IN CENTRAL-NERVOUS-SYSTEM AND CIRCULATION [J].

GIJBELS, K ;

BROCKE, S ;

ABRAMS, JS ;

STEINMAN, L .

MOLECULAR MEDICINE, 1995, 1 (07) :795-805

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