A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi

被引：138

作者：

Barr, SC

Warner, KL

Kornreic, BG

Piscitelli, J

Wolfe, A

Benet, L

McKerrow, JH

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[3] Albert Einstein Coll Med, Dept Clin Pathol, Bronx, NY 10461 USA

[4] Cornell Univ, Sch Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 12期

关键词：

D O I：

10.1128/AAC.49.12.5160-5161.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.

引用

页码：5160 / 5161

页数：2

共 8 条

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