Effector lymphocytes in autoimmunity

被引：65

作者：

Santamaria, P ^{[1
]}

机构：

[1] Univ Calgary, Fac Med, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 06期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S0952-7915(01)00276-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases result from complex interactions among different T- and B-lymphocyte subpopulations that target a rapidly growing number of autoantigens on different cell types. The etiology of most spontaneous autoimmune disorders, and both the kinetics and hierarchy of the underlying autoimmune responses are poorly understood. However, important advances have been made in recent years in our understanding of how autoreactive lymphocytes cause tissue damage, including the discovery that granzyme B binds to a cell surface receptor on target cells. This review is an attempt to summarize recent developments in this area.

引用

页码：663 / 669

页数：7

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