Induction of anticardiolipin antibody and/or lupus anticoagulant in rabbits by immunization with lipoteichoic acid, lipopolysaccharide and lipid A

被引：19

作者：

Gotoh, M ^{[1
]}

Matsuda, J ^{[1
]}

机构：

[1] TEIKYO UNIV,SCH MED,DEPT MED,ITABASHI KU,TOKYO 173,JAPAN

来源：

LUPUS | 1996年 / 5卷 / 06期

关键词：

anticardiolipin antibody; lupus anticoagulant; microorganism derivative;

D O I：

10.1177/096120339600500606

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It still remains unclear how anti-phospholipid antibody develops in a specific patient group, however, it is possible that certain microorganism(s) may cause anti-cardiolipin antibody (aCL) development since aCL is frequently detected in patients with Treponema pallidum (TP) and/or other infectious diseases. Accordingly, we conducted an investigation to clarify whether or not anticardiolipin antibody (aCL) and/or lupus anticoagulant (LA) can be induced in rabbits by immunization with Gram-positive or -negative microorganism derivatives, such as lipoteichoic acid, lipopolysaccharide and lipid A. We detected the induction of SLE type-aCL (beta(2)GPI-dependent) and LA in some rabbits immunized with lipid A and lipoteichoic acid, thereby suggesting that some microorganisms may contribute to even the production of pathogenic (SLE-type) antiphospholipid antibody.

引用

页码：593 / 597

页数：5

共 14 条

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