FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

被引：115

作者：

Roncador, G

Garcia, JF

Maestre, L

Lucas, E

Menarguez, J

Ohshima, K

Nakamura, S

Banham, AH

Piris, MA

机构：

[1] Ctr Nacl Invest Oncol, Monoclonal Antibodies Unit, Biotechnol Program, Madrid 28029, Spain

[2] Ctr Nacl Invest Oncol, Mol Pathol Program, Madrid 28029, Spain

[3] Hosp Gen Gregorio Maranon, Dept Pathol, Madrid, Spain

[4] Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 81401, Japan

[5] Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Nagoya, Aichi 464, Japan

[6] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England

来源：

LEUKEMIA | 2005年 / 19卷 / 12期

关键词：

FOXP3; monoclonal antibody; lymphoma; regulatory T-cell; adult T-cell leukaemia-lymphoma;

D O I：

10.1038/sj.leu.2403965

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FOXP3 is a forkhead transcription factor family member, implicated in T-cell regulation, activation and differentiation. FOXP3 has been shown to be a master control gene for the development and function of CD4+/CD25+ regulatory T-cells (T-reg). In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples. FOXP3 expression in tumour cells was confined to adult T-cell leukaemia/lymphoma (ATLL) cases (17/25, 68%), with some variability in the intensity of the staining and the proportion of positive cells. No other lymphoma types studied exhibited FOXP3 expression in the malignant population. The selective expression of FOXP3 by tumour cells in ATLL makes this antibody a potentially useful diagnostic tool.

引用

页码：2247 / 2253

页数：7

共 27 条

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