Relationship between adipokines and manifestations of childhood asthma

被引:96
作者
Kim, Kyung W. [1 ,2 ]
Shin, Youn H. [3 ]
Lee, Kyung E. [1 ,2 ]
Kim, Eun S. [1 ,2 ]
Sohn, Myung H. [1 ,2 ]
Kim, Kyu-Earn [1 ,2 ]
机构
[1] Yonsei Univ, Coll Med, Dept Pediat, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Inst Allergy, Res Ctr Human Nat Def Syst,Brain Korea Project Me, Seoul 120752, South Korea
[3] Univ Coll Med, Pochon CHA, Dept Pediat, Seoul, South Korea
关键词
adiponectin; asthma; child; leptin; resistin;
D O I
10.1111/j.1399-3038.2007.00690.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 [免疫学];
摘要
Although the prevalences of asthma and obesity are increasing substantially in recent decades, very little is known about the possible association between them. We evaluated the roles of leptin, adiponectin, and resistin, which are adipokines produced by adipose tissue, on childhood asthma, and their association with pulmonary function and bronchial hyperresponsiveness. We studied 149 atopic asthmatic children, 37 non-atopic asthmatic children, and 54 healthy children. Body mass index was calculated using height and weight, which were measured on the same day that pulmonary function tests and methacholine challenge tests were performed. Skin prick tests were performed, and total eosinophil count, total serum immunoglobulin E (IgE), serum eosinophil cationic protein, leptin, adiponectin, and resistin were measured in all subjects. Atopic asthmatics had lower resistin levels compared with non-atopic asthma and control groups, but leptin and adiponectin did not show any difference among these three groups. Resistin demonstrated positive correlation with methacholine PC20 and negative correlations with eosinophil count and serum total IgE. Leptin and adiponectin showed associations with forced expiratory volume in 1 s or forced expiratory flow between 25-75%. Multiple regression analysis revealed that resistin was a significant predictive factor for asthma. There was no direct association between asthma and leptin or adiponectin. Our findings suggest that resistin may play a negative predictive role in asthma. Adiponectin and leptin showed close associations with pulmonary function and may have disease-modifying effects in children with asthma.
引用
收藏
页码:535 / 540
页数:6
相关论文
共 30 条
[1]
Identification of leptin receptors in lung and isolated fetal type II cells [J].
Bergen, HT ;
Cherlet, TC ;
Manuel, P ;
Scott, JE .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 27 (01) :71-77
[2]
Pulmonary perspective - Obesity and asthma [J].
Beuther, David A. ;
Weiss, Scott T. ;
Sutherland, E. Rand .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (02) :112-119
[3]
The relationship between asthma and obesity in children: Is it real or a case of over diagnosis? [J].
Bibi, H ;
Shoseyov, D ;
Feigenbaum, D ;
Genis, M ;
Friger, M ;
Peled, R ;
Sharff, S .
JOURNAL OF ASTHMA, 2004, 41 (04) :403-410
[4]
Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years [J].
Castro-Rodríguez, LA ;
Holberg, CJ ;
Morgan, WJ ;
Wright, AL ;
Martinez, FD .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (06) :1344-1349
[5]
Can the increase in body mass index explain the rising trend in asthma in children? [J].
Chinn, S ;
Rona, RJ .
THORAX, 2001, 56 (11) :845-850
[6]
Establishing a standard definition for child overweight and obesity worldwide: international survey [J].
Cole, TJ ;
Bellizzi, MC ;
Flegal, KM ;
Dietz, WH .
BMJ-BRITISH MEDICAL JOURNAL, 2000, 320 (7244) :1240-1243
[7]
Crapo RO, 2000, AM J RESP CRIT CARE, V161, P309
[8]
Adipose tissue, adipokines, and inflammation [J].
Fantuzzi, G .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (05) :911-919
[9]
The epidemiology of obesity and asthma [J].
Ford, ES .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (05) :897-909
[10]
Body-mass index as a predictor of incident asthma in a prospective cohort of children [J].
Gold, DR ;
Damokosh, AI ;
Dockery, DW ;
Berkey, CS .
PEDIATRIC PULMONOLOGY, 2003, 36 (06) :514-521